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- Rai Balwant
- Department of Dentistry, Government Dental College
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- Kharb Simmi
- Department of Biochemistry, Post Graduate Institute of Medical Science
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- Jain Rajnish
- Department of Dentistry, Government Dental College
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- Anand Suresh C.
- Department of Dentistry, Government Dental College
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説明
Matrix metalloproteinases (MMPs), the key enzymes responsible for matrix degradation, are derived from polymorphonuclear leukocytes during the early stages of periodontitis. The present study determined the levels of GCF matrix metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) and salivary MMP-8 in patients with gingivitis and periodontitis and in healthy controls. Levels of crevicular MMP-2, MMP-9 and salivary MMP-8 were determined by ELISA in subjects with healthy gingiva (n = 15), gingivitis (n = 18) and periodontitis (n = 20). Significantly higher salivary MMP-8 and crevicular MMP-9 were observed in cases of periodontitis compared to gingivitis and healthy adults. On the other hand, crevicular MMP-2 levels in periodontitis subjects were lower than those in gingivitis and healthy subjects. The three MMP levels were highly correlated to probing depth, and bleeding on probing. Salivary MMP-8, crevicular MMP- 2 and 9 may serve as biomarkers of periodontal disease and aid in early detection of periodontitis or gingivitis. (J. Oral Sci. 50, 53-56, 2008)
収録刊行物
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- Journal of Oral Science
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Journal of Oral Science 50 (1), 53-56, 2008
日本大学歯学部
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詳細情報 詳細情報について
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- CRID
- 1390282680022408832
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- NII論文ID
- 130000072861
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- ISSN
- 18804926
- 13434934
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可