Phenotypic Analysis of Vertigo 2 Jackson Mice with a Kcnq1 Potassium Channel Mutation

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  • TAKAGI Takeshi
    Departments of Legal Medicine, Osaka Medical College Departments of General and Gastroenterological Surgery, Osaka Medical College
  • NISHIO Hajime
    Departments of Legal Medicine, Osaka Medical College
  • YAGI Takeo
    Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
  • KUWAHARA Masayoshi
    Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
  • TSUBONE Hirokazu
    Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
  • TANIGAWA Nobuhiko
    Departments of General and Gastroenterological Surgery, Osaka Medical College
  • SUZUKI Koichi
    Departments of Legal Medicine, Osaka Medical College

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Abstract

The KCNQ1 gene encodes a voltage-dependent potassium ion channel, and mutations in this gene are the most common cause of congenital long QT syndrome (LQTS). In the present study, we investigated the various phenotypic characteristics of vertigo 2 Jackson (C3H/HeJCrl-Kcnq1vtg-2J/J) mice with a Kcnq1 mutation. Both heterozygotes (vtg-2J/+) and homozygotes (vtg-2J/vtg-2J) showed prolonged QT intervals in electrocardiograms (ECGs) compared to C3H/HeJ control (+/+) mice. Furthermore, vtg-2J/vtg-2J mice showed gastric achlorhydria associated with elevation of their serum gastrin levels. The serum corticosterone levels were also significantly increased in vtg-2J/vtg-2J mice. In addition, vtg-2J/vtg-2J mice exhibited significantly higher blood pressure. These findings indicate that the Kcnq1 mutation in vtg-2J mice alters various physiological functions in the cardiac, gastric and adrenocortical systems, and suggest that vtg-2J mice may represent a useful model for studying Kcnq1 functions.<br>

Journal

  • Experimental Animals

    Experimental Animals 56 (4), 295-300, 2007

    Japanese Association for Laboratory Animal Science

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