Identification of QTLs Involved in the Development of Amygdala Kindling in the Rat

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  • Hashimoto Ryoko
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
  • Voigt Birger
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
  • Ishimaru Yuji
    Department of Psychiatry and Neurology, Asahikawa Medical College, 2-1-1-1 Midorigaoka higashi, Asahikawa 078-8510, Japan
  • Hokao Ryoji
    Institute of Animal Reproduction, 1103 Fukaya, Kasumigaura 300-0134, Japan
  • Chiba Shigeru
    Department of Psychiatry and Neurology, Asahikawa Medical College, 2-1-1-1 Midorigaoka higashi, Asahikawa 078-8510, Japan
  • Serikawa Tadao
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
  • Sasa Masashi
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
  • Kuramoto Takashi
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan

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Amygdala kindling is useful for modeling human epilepsy development. It has been known that genetic factors are involved in the development of amygdala kindling. The purpose of this study was to identify the loci that are responsible for the development of amygdala kindling. To achieve this, rat strains from a LEXF/FXLE recombinant inbred (RI) strain panel were used. The phenotypes of amygdala kindling-related parameters for seven RI strains and parental LE/Stm and F344/Stm strains were determined. They included the afterdischarge threshold (ADT), the afterdischarge duration (ADD), and the kindling rate, an incidence of development of kindling. Quantitative trait loci (QTL) analysis was performed to identify linkage relationships between these phenotypes and 1,033 SNP markers. Although no significant differences in pre-kindling ADT and ADD were observed, a significant difference in the kindling rate was found for the LEXF/FXLE RI strain. Two QTLs for the amygdala kindling rate (Agkr1 and Agkr2) were identified on rat chromosome 2. These findings clearly prove the existence of genetic influences that are involved in kindling development and suggest that substantial genetic components contribute to the progression of partial seizures into generalized seizures.

収録刊行物

  • Experimental Animals

    Experimental Animals 62 (3), 181-187, 2013

    公益社団法人 日本実験動物学会

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