Phenotypes of IRS-2 Deficient Mice Produced by Reproductive Technology are Stable
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- HASHIMOTO Haruo
- Central Institute for Experimental Animals
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- ARAI Toshiro
- Department of Veterinary Biochemistry, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
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- OHNISHI Yasuyuki
- Central Institute for Experimental Animals
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- ETO Tomoo
- Central Institute for Experimental Animals
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- ITO Mamoru
- Central Institute for Experimental Animals
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- HIOKI Kyoji
- Central Institute for Experimental Animals
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- SUZUKI Ryo
- Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
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- YAMAUCHI Toshimasa
- Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
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- OHSUGI Mitsuru
- Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
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- SAITO Muneo
- Central Institute for Experimental Animals
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- UEYAMA Yoshito
- Department of Pathology, Tokai University School of Medicine
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- TOBE Kazuyuki
- Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
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- KADOWAKI Takashi
- Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
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- TAMAOKI Norikazu
- Central Institute for Experimental Animals
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- KOSAKA Kinori
- Central Institute for Experimental Animals Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
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We studied the impact of "IVF - ET" on the glucose tolerance test (GTT), insulin tolerance test (ITT) and adiponectin to investigate differences in the phenotypes of B6J- Irs2-/- mice. The B6J-Irs2-/- mice (KO-Nat group) were prepared by natural mating. Other mice were produced by IVF-ET used ICR strain recipients and surrogate mothers (KO-IVF group). Measurement of body weight, GTT, ITT and blood sampling were performed at the ages of 6, 14 and 24 weeks after birth. Body weights, impaired glucose tolerance, insulin resistance and plasma adiponectin concentrations did not differ for each gender between the KO-IVF and KO-Nat groups. Therefore, we concluded that phenotypes of Irs2-/- mice produced by reproductive technology are stable.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 56 (2), 149-154, 2007
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390282680023233280
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- NII論文ID
- 130000068045
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 8704432
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
