Dose Finding Study of Cefepime for Chronic Respiratory Infections

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  • SAITO Atsushi
    The First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
  • SHIGENO Yoshiteru
    The First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
  • IRABU Yuei
    The First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
  • FUKUHARA Hiroshi
    The First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
  • SAITO Akira
    The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospital
  • NAKAYAMA Ichiro
    The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospital
  • HIRAGA Yohmei
    Department of Respiratory Diseases, Sapporo Hospital, Hokkaido Railway Company
  • OHMICHI Mitsuhide
    Department of Respiratory Diseases, Sapporo Hospital, Hokkaido Railway Company
  • OIZUMI Kotaro
    Department of Internal Medicine, The Research Institute for Chest diseases and Cancer, Tohoku University
  • WATANABE Akira
    Department of Internal Medicine, The Research Institute for Chest diseases and Cancer, Tohoku University
  • HAYASHI Izumi
    Department of Respiratory Diseases, Iwaki Kyoritsu General Hospital
  • SHIMADA Kaoru
    Department of Infectious Diseases, Institute of Medical Science, University of Tokyo and Related Hospital
  • SANO Yasuyuki
    Department of Infectious Diseases, Institute of Medical Science, University of Tokyo and Related Hospital
  • ARAI Yasuo
    Department of Infectious Diseases, Institute of Medical Science, University of Tokyo and Related Hospital
  • SUZUKI Naohito
    Department of Infectious Diseases, Institute of Medical Science, University of Tokyo and Related Hospital
  • KOBAYASHI Hiroyuki
    The First Department of Internal Medicine, Kyorin University, School of Medicine
  • OSHITANI Hiroshi
    The First Department of Internal Medicine, Kyorin University, School of Medicine
  • INOUE Hisashi
    The First Department of Internal Medicine, Kyorin University, School of Medicine
  • SHIMADA Jingoro
    The Second Department of Internal Medicine, The Jikei University School of Medicine
  • SHIBA Kohya
    The Second Department of Internal Medicine, The Jikei University School of Medicine
  • KAJI Masanobu
    The Second Department of Internal Medicine, The Jikei University School of Medicine
  • SAKAI Osamu
    The Second Department of Internal Medicine, The Jikei University School of Medicine
  • TANIMOTO Hiroichi
    Department of Respiratory Disease, Toranomon Hospital
  • NAKATA Koichiro
    Department of Respiratory Disease, Toranomon Hospital
  • NAKAMORI Yoshitaka
    Department of Respiratory Disease, Toranomon Hospital
  • CHONABAYASHI Naohiko
    Department of Respiratory Disease, Toranomon Hospital
  • NOGUCHI Masayuki
    Department of Respiratory Disease, Toranomon Hospital
  • MATSUMOTO Fumio
    Department of Internal Medicine, Kanagawa Prefectural Nursing and Hygienic School Hospital
  • SAKURAI Iwao
    Department of Internal Medicine, Kanagawa Prefectural Nursing and Hygienic School Hospital
  • ODAGIRI Shigeki
    Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
  • MATSUMURA Masanori
    Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
  • SUZUKI Kaneo
    Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
  • YAMAMOTO Toshiyuki
    Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital
  • SUZUKI Kanzo
    Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital
  • ADACHI Satoru
    Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital
  • NARITA Nobuhiro
    The Second Department of Internal Medicine, Nara Medical University
  • SAWAKI Masayoshi
    The Second Department of Internal Medicine, Nara Medical University
  • MIKASA Keiichi
    The Second Department of Internal Medicine, Nara Medical University
  • MIKI Fumio
    Department of Internal Medicine, Tane General Hospital
  • SOEJIMA Rinzo
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
  • NIKI Yoshihito
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
  • HINO Jiro
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
  • SUMI Masaru
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
  • KIMURA Masashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
  • TATARA Osamu
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
  • MATSUSHIMA Toshiharu
    The Second Department of Medicine, Kawasaki Medical School, Kawasaki Hospital
  • KAWANISHI Masayoshi
    The Second Department of Medicine, Kawasaki Medical School, Kawasaki Hospital
  • HARA Kohei
    The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
  • YAMAGUCHI Keizo
    The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
  • KOHNO Shigeru
    The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
  • ARAMAKI Takahisa
    The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
  • TANAKA Yoshito
    The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
  • KUDO Keizo
    The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
  • IWAMOTO Masanori
    The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
  • MUKAI Hiroshi
    The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
  • ISHINO Toru
    The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
  • FUJIWARA Tsuneo
    The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
  • MATSUMOTO Keizo
    Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
  • OISHI Kazunori
    Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
  • NASU Masaru
    Second Department of Internal Medicine, Medical College of Oita
  • GOTO Yoichiro
    Second Department of Internal Medicine, Medical College of Oita
  • GOTO Jun
    Second Department of Internal Medicine, Medical College of Oita
  • TASHIRO Takayoshi
    Second Department of Internal Medicine, Medical College of Oita
  • OGAWA Nobuya
    Pharmacology, Ehime University, School of Medicine
  • KUSANO Nobuchika
    Central Clinical Laboratory, University of the Ryukyus Hospital

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Other Title
  • 慢性気道感染症に対するcefepimeの臨床用量比較試験成績
  • マンセイ キドウ カンセンショウ ニ タイスル cefepime ノ リンショ

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Abstract

In order to determine the optimal dose of cefepime (CFPM) for respiratory tract infections, a dose finding study was conducted in patients with chronic respiratory tract infections, and the clinical properties of the drugs were compared with those of ceftazidime (CAZ).<BR>Each drug was administered by intravenous drip infusion at the dose of 2 g/day of CFPM, 4g/day of CFPM or 2g/day of CAZ for 14 days.<BR>1. The overall efficacy rates evaluated by the committee were 82.6%(19/23) for the CFPM 2g/day group, 85.0%(17/20) for the 4g/day group and 79.3%(23/29) for the CAZ 2g/day group, with no statistically significant difference among the three groups.<BR>2. The overall efficacy rates evaluated by the attending physicians were 91.3%(21/23) for the CFPM 2g/day group, 78.9%(15/19) for the CFPM 4g/day group and 75.9%(22/29) for the CAZ 2g/day group, with no significantdifferenceerence among the three groups.<BR>3. Bacteriological eradication rates were 88.2%(15/17) for the CFPM 2g/day group, 68.8%(11/16) for the CFPM 4g/day group and 63.2%(12/19) for the CAZ 2g/day group, with no statistically significant difference among the three groups.<BR>4. The incidences of adverse reactions were 3.8%(1/26) for the CFPM 2g/day group, 9.1%(2/22) for the CFPM 4g/day group and 3.4%(1/29) for the CAZ 2g/day group, with no significant difference among the three groups. The incidences of abnormal laboratory findings were 37.5%(9/24) for the CFPM 2g/day group, 15.0%(3/20) for the CFPM 4g/day group and 3.4%(1/29) for the CAZ 2g/day group. There was a significant difference erence among the three groups.<BR>5. Utility rates assessed by the committee were 81.8%(18/22) for the CFPM 2g/day group, 76.2%(16/21) for the CFPM 4g/day group and 75.9%(22/29) for the CAZ 2g/day group. Utility rates assessed by attending physicians were 90.9%(20/22), 78.9%(15/19) and 72.4%(21/29), respectively. There was no significant difference among the three groups.<BR>From the above results, it is concluded that the optimal dosage of CFPM is 2g/day for chronic respiratory tract infections.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 66 (7), 837-858, 1992

    The Japanese Association for Infectious Diseases

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