Body and Major Organ Weights of A/J-Chr 11SM Consomic Mice

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  • TANAKA Shin
    Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)
  • MIZOROGI Toshihiro
    Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)
  • NISHIJIMA Kazutoshi
    Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)
  • KUWAHARA Sachi
    Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG) Department of Anatomy, Hyogo College of Medicine
  • TSUJIO Masashi
    Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)
  • AOYAMA Hiroaki
    Institute for Environmental Toxicology
  • TAGUCHI Chie
    Laboratory of Animal Nutrition, Department of Applied Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University
  • KOBAYASHI Misato
    Laboratory of Animal Nutrition, Department of Applied Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University
  • HORIO Fumihiko
    Laboratory of Animal Nutrition, Department of Applied Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University
  • OHNO Tamio
    Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate School of Medicine, Nagoya University

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The body and major organ weights of A/J-Chr 11SM consomic mice were compared to those of the progenitor strains, A/J and SM/J. The weights of the body and organs, except for those of the brain and uterus, were significantly greater in A/J mice than in SM/J mice. However, those of consomic mice were highly variable. For example, the average body weight of consomic mice was significantly greater than that of SM/J mice and nearly equal to that of A/J mice. Chromosome 11 of SM/J mice induced various significant changes of the organ weights of A/J mice, especially those of the brain, lung, kidney, adrenal, and ovary, demonstrating the importance of this chromosome in determining the phenotypes.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 58 (4), 357-361, 2009

    公益社団法人 日本実験動物学会

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