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Transcutaneous Cisternal Puncture for Sampling of Cerebrospinal Fluid in Awake Rat
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- TAKASUGI Yoshihiro
- Department of Anesthesiology, Kinki University School of Medicine
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- SHIRAI Toru
- Department of Anesthesiology, Kinki University School of Medicine
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- FUTAGAWA Koichi
- Department of Anesthesiology, Nara Hospital, Kinki University School of Medicine
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- KOGA Yoshihisa
- Department of Anesthesiology, Kinki University School of Medicine
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- EGAWA Kentaro
- Life Science Research Institute, Kinki University School of Medicine
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- WATANABE Shinsuke
- Life Science Research Institute, Kinki University School of Medicine
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- UMEDA Takashi
- Department of Clinical Acupuncture, Osaka Kansai College of Oriental Medicine
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Description
Reported cisternal puncture methods require the anesthetization and fixation of an animal within a stereotaxic frame. To determine the effect of anesthesia and animal fixation on the central nervous system (CNS), amino acid concentrations of cerebrospinal fluid (CSF) sampled by transcutaneous cisternal puncture were compared among awake rats, pentobarbital-anesthetized rats and pentobarbital-anesthetized rats fixed in a stereotaxic frame. Although the concentrations of many amino acids in the CSF of pentobarbital-anesthetized rats were lower than in awake rats, use of the stereotaxic frame resulted in significantly increased amino acid concentrations in the CSF. These data indicate that CSF sampling by transcutaneous cisternal puncture from awake rats is a suitable method for serial measurement of drug effects on the CNS.<br>
Journal
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- Experimental Animals
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Experimental Animals 54 (2), 193-196, 2005
Japanese Association for Laboratory Animal Science
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Keywords
Details 詳細情報について
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- CRID
- 1390282680023742080
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- NII Article ID
- 10015525986
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- NII Book ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL BIB ID
- 7304466
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- PubMed
- 15897631
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed