Change in Ucp1 mRNA Expression Following Long-Term Cold Exposure under Normal or High-Fat Diet Regimes in the Cold-Intolerant Mammal, Suncus murinus
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- SUZUKI Daisuke
- Laboratory of Animal Management & Resources, School of Bio-Agricultural Sciences Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University
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- MURATA Yoshiharu
- Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University
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- ODA Sen-ichi
- Laboratory of Animal Management & Resources, School of Bio-Agricultural Sciences
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Abstract
The house musk shrew (Suncus murinus), or suncus, is a unique experimental mammal that is cold intolerant. However, even basic knowledge of brown adipose tissue (BAT), which is important for non-shivering thermogenesis (NST), is minimal. Therefore, we exposed suncus for 18 days to mild cold temperatures (8-14°C) and/or a high-fat diet, which are factors that increase NST, and measured two mRNAs that are critical for NST in BAT, uncoupling protein 1 (Ucp1) and type II 5'-deiodinase (D2). Neither mild cold exposure nor a high-fat diet alone induced up-regulation of the mRNAs. However, combinations of cold exposure and high-fat diet significantly increased both mRNAs. Therefore, cold intolerance in suncus may be partly caused by dietary components.<br>
Journal
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- Experimental Animals
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Experimental Animals 55 (5), 467-471, 2006
Japanese Association for Laboratory Animal Science
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Details 詳細情報について
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- CRID
- 1390282680023817472
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- NII Article ID
- 130000068078
- 30010197151
- 10018307889
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- NII Book ID
- AA11032321
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- COI
- 1:CAS:528:DC%2BD28Xht1ylt7%2FP
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL BIB ID
- 8089693
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed