Podoplanin expression in odontomas: clinicopathological study and immunohistochemical analysis of 86 cases
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- González-Alva Patricia
- Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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- Inoue Harumi
- Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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- Miyazaki Yuji
- Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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- Tsuchiya Hozumi
- Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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- Noguchi Yoshihiro
- Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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- Kikuchi Kentaro
- Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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- Ide Fumio
- Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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- Ishihara Sachiyo
- Division of Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry
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- Katayama Tadashi
- Division of Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry
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- Sakashita Hideaki
- Division of Oral & Maxillofacial Surgery II, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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- Kusama Kaoru
- Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
Bibliographic Information
- Other Title
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- Podoplanin expression in odontomas: clinicopathological study and immunohistichemical analysis of 86 cases
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Description
Podoplanin, a sialomucin-lik e transmembrane glycoprotein, is currently used as a specific marker for lymphatic vessels. However, podoplanin expression has also been linked to tooth development. To investigate the expression of podoplanin in odontomas, 86 tissue samples were classified and then analyzed using immunohistochemical methods. Formalin-fixed, paraffin-embedded specimens were collected and classified, followed by immunohistochemical examination. The majority of the odontomas (66.3%) were the compound type, and the remainder (33.7%) were the complex type. The patients ranged in age from 2 to 89 years (mean, 23.9 years), and 45 (52.3%) of them were male and 41 (47.7%) were female. The most common location for complex odontomas was the molar region of the mandibular bone, and that for compound odontomas was the maxillary incisor region. Immunohistochemistry revealed that developing and mature odontoblasts, Tomes' fibers, and pulp cells near podoplanin-positive odontoblasts were positive for podoplanin. In addition, podoplanin positivity was evident in secretory ameloblasts, but not in mature ameloblasts. The pattern of podoplanin expression in odontomas corresponds to development of the tooth germ, and appears to be influenced by the stage of differentiation of the lesion, suggesting that the protein may participate in the process of differentiation. (J Oral Sci 53, 67-75, 2011)
Journal
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- Journal of Oral Science
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Journal of Oral Science 53 (1), 67-75, 2011
Nihon University School of Dentistry