[Updated on Apr. 18] Integration of CiNii Articles into CiNii Research

Different sensitivity to the suppressive effects of isoflurane anesthesia on cardiorespiratory function in SHR/Izm, WKY/Izm, and Crl:CD (SD) rats

  • Kato Kouki
    Center for Laboratory Animal Science, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
  • Wakai Jun
    Department of Laboratory Animal Medicine, Institute for Biomedical Sciences, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba-cho, Shiwa-gun, Iwate 028-3694, Japan
  • Ozawa Kazunori
    Medical-Industrial Translational Research Center, Fukushima Global Science Center, Fukushima Medical University, 1-Hikarigaoka, Fukushima, Fukushima 960-1295, Japan
  • Sekiguchi Miho
    Medical-Industrial Translational Research Center, Fukushima Global Science Center, Fukushima Medical University, 1-Hikarigaoka, Fukushima, Fukushima 960-1295, Japan Laboratory Animal Research Center, Fukushima Medical University School of Medicine, 1-Hikarigaoka, Fukushima, Fukushima 960-1295, Japan
  • Katahira Kiyoaki
    Medical-Industrial Translational Research Center, Fukushima Global Science Center, Fukushima Medical University, 1-Hikarigaoka, Fukushima, Fukushima 960-1295, Japan

Search this article

Abstract

<p>Isoflurane is a widely used anesthetic, but its effects with increase in inspired concentration on cardiovascular function have not yet been clarified in rodents. Additionally, there are only a few studies comparing isoflurane-induced cardiorespiratory effects between rat strains. Thus, we investigated the differences in cardiorespiratory responsiveness to increasing concentration of inspired isoflurane in SHR/Izm, WKY/Izm and Crl:CD (SD) rats, by increasing the setting values of vaporizer’s dial indicator. The rats were anesthetized with 1.5% isoflurane, and electrocardiograms, blood pressure, and respiratory rate were recorded simultaneously. Thereafter, the inspired concentration was increased stepwise to 2%, 3%, 4%, and 5%, and cardiorespiratory parameters were obtained at each concentration. Under anesthesia at more than 4%, although prolongation of the RR and PR intervals was observed in all strains, shortening of the QTC interval was found only in SHR/Izm rats. From frequency domain analysis of heart rate variability, an increase in LF/HF ratio and a decrease of HF components were observed in SHR/Izm and WKY/Izm rats, respectively, with 5% isoflurane anesthesia. Blood pressure and heart rate were remarkably reduced in SHR/Izm rats at higher concentrations, whereas the reduction was smallest in WKY/Izm rats among the three strains examined. Respiratory rate was inspired concentration-dependently decreased in all strains. These results suggested that SHR/Izm rats are more sensitive to suppressive effects of isoflurane anesthesia on cardiovascular function among these rat strains.</p>

Journal

  • Experimental Animals

    Experimental Animals 65 (4), 393-402, 2016

    Japanese Association for Laboratory Animal Science

Citations (2)*help

See more

References(35)*help

See more

Related Articles

See more

Related Data

See more

Related Books

See more

Related Dissertations

See more

Related Projects

See more

Related Products

See more

Details

Report a problem

Back to top