呼吸器感染症に対するCefotaxime 4gとCefazolin 4gの薬効比較試験

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タイトル別名
  • Comparative Study of the Effectiveness of Cefotaxime and Cefazolin on Respiratory Tract Infection
  • コキュウキ カンセンショウ ニ タイスル Cefotaxime4g ト Cef

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The efficacy and safety of cefotaxime (CTX, HR 756) and cefazolin (CEZ) were objectively evaluated in a well-controlled study of respiratory tract infections at 38 institutions in Japan. Patients with pneumonia or chronic respiratory tract infections were given intravenous drip infusions of either CTX or CEZ, randomly assigned, at 4 g per day in two divided doses for, in principle, 14 days. The therapeutic efficacy, adverse reactions, and usefulness of the drugs were evaluated by intergroup comparison.The following results were obtained:<BR>1.There was no statistically significant intergroup difference in therapeutic efficacy.<BR>2.Among patients in which the causative organisms were able to be determined, the bacteriological efficacy of CTX, in terms of eradication rate, was significantly superiorto that of CEZ.<BR>3.There was no significant intergroup difference in the incidence of side effects<BR>4.There was no significant intergroup difference in usefulness.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 54 (11), 627-693, 1980

    一般社団法人 日本感染症学会

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