菌血性疾患に関する研究第2報

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タイトル別名
  • Studies on Bacteremic Disease 2
  • アキュウセイ サイキンセイシン ナイ マクエン ニ タイスル ペニシリン G , ナラビニ セフアロスポリンケイ コウセイザイ ノ タイリョウ リョウホウ コウカ ト フクサヨウ ニ ツイテ
  • Treatment of Subacute Bacterial Endocarditis with Large Doses of Penicillin G and Cephalosporin Antibiotics. On the Clinical Effectiveness and Side Effects
  • 亜急性細菌性心内膜炎に対するペニシリンG, ならびにセフアロスポリン系抗生剤の大量療法効果と副作用について

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説明

Three patients with subacute bacterial endocarditis were treated with large doses of penicillin G and cephalosporin antibiotics. Minimum inhibitory concentrations of penicillin G for streptococci isolated from three patients were 0.1mcg/ml or less. Those of cephaloridine were 0.1mcg/ml for 2 strains from case 1 and 2, and 0.5mcg/ml for the other one from case 3, respectively.<BR>In case 1 infected with streptococcus lactis, the treatment with 18 million units of penicillin G per day failed to cure and daily 14 g of cephalothin combined with 6 g of cephaloridine caused renal impairment and hypersensitivity phenomena, i.e. high fever, thrombophlebitis in the site of intravenous drip, exanthema, liver enlargement, elevation of GPT, and leukemoid reaction. Cure was achieved by the daily use of 28.8 million units of penicillin G, and sodium polystylene sulfonate (Kayexalate ®) was effective on hyperpotassemia of 7.6 meq/L caused by large doses of potassium penicillin G in the circumstance of renal impairment. Total dosis of penicillin G used was 2805 million units.<BR>Case 2 infected with streptococcus dysgalactiae was treated with 6 g per day of cephaloridine and cured without any side effect. Total dosis of cephaloridine used was 195 g. In case 3 infected with streptococcus mitis, treatments with 6 g per day of cephaloridine and 29 million units of penicillin G plus 2 g of streptomycin in every day failed to cure, respectively. The infection was suppressed by the dosis of 44 million units per day of penicillin G but symptoms of aortic insufficiency were remained after the completion of chemotherapy. Total dosis of penicillin G used was 2470 million units but no hyperpotassemia appeared.<BR>Another phenomenon observed in each patient was appearance of broad albumin band on the serum electrophoresis. This seemed to be due to binding of penicillin G and cephalosporin antibioitcs to serum albumin. No coomb's positive reaction was observed.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 48 (3), 80-87, 1974

    一般社団法人 日本感染症学会

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