インフルエンザ菌性慢性呼吸器感染症の基礎的臨床的研究

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書誌事項

タイトル別名
  • Respiratory Infection due to Haemophilus influenzae
  • インフルエンザ菌性慣性呼吸器感染症の基礎的臨床的研究
  • インフルエンザキンセイ カンセイ コキュウキ カンセンショウ ノ キソテキ リンショウテキ ケンキュウ

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1) Between January and October in 1972, the survey of 140 patients with respiratory infection revealed significant number of microorganisms in sputum. Haemophilus influenzae forms 29.3 per cent of those microorganisms.<BR>2) Serotypes of 100 Haemophilus influenzae strains isolated from sputa were as follows: nontypable 62, type-d 23, type-a 6, type-b 2, type-c 1, mixed type 6.<BR>3) 120 patients with Haemophilus influenzae respiratory infection were made up of acute infection of 9.2 per cent, chronic infection 67.5 per cent and the others 23.3 per cent.<BR>4) Haemophilus influenzae respiratory infection is ecologically classifiable into 3 types, I to III. Type-I is most frequent, and type-III is least.<BR>5) The mechanisms of induction and colonization of Haemophilus influenzae into respiratory tract were devided into 5 types.<BR>i) secondary infection following viral infection<BR>ii) acute exacervation type<BR>iii) canal infection type<BR>iv) drug induced type<BR>v) antibiotic error<BR>6) We devised quantitative analysis of Growth Factor of Haemophilus influenzae in sputum.<BR>7) Serum precipitins against Haemophilus influenzae were highly detected in patients with chronic respiratory infection.<BR>8) Susceptibility of Haemophilus influenzae to 19 antibiotics was examined. Ampicillin was most effective in them.<BR>9) Electron microscopic studies revealed that the antibiotic mechanism of Ampicillin to Haemophilus influenzae mainly depends on the effect to cell wall, and protoplasts of them were produced.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 48 (4), 117-125, 1974

    一般社団法人 日本感染症学会

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