赤痢症状に対する薬剤効果の一判定基準

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書誌事項

タイトル別名
  • A Criteria for Clinical Evaluation of Antibiotics on Symptoms of Bacillary Dysentery
  • 赤痢症状に対する薬剤効果の一判定基準-3-薬効評価のための要因について
  • セキリ ショウジョウ ニ タイスル ヤクザイ コウカ ノ イチハンテイ キジュ
  • III. Factors for Evaluation of Drug Effect
  • III薬効評価のための要因について

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抄録

An acute infectious disease like bacillary dysentery has a strong tendency for natural recovery.<BR>In such a case, the factors of parasite and host have a great influence on the evaluation of the clinical effect of antibiotics.<BR>In this report, bacterial group and sensitivity to antibiotics were considered as bacterial factors, along with host factors of sex, age and severity of symptoms, while the day of illness on which medication was begun and its duration of use was considered as the condition of medication, etc. The effect of each on the clinical course was examined to determine what should be taken or left out of the above factors in evaluating the clinical effect.<BR>In this study, the severity of initial symptoms and duration of illness were expressed by numerical values and analyzed mathematically. Scores were based upon the tables explained in the first and second reports of this series.<BR>The result was that bacterial group, age, and severity of symptoms at the start of medication significantly influenced the clinical course. Accordingly, these factors should be further considered in the comparative studies of antibiotics, even if the condition of medication is fixed.<BR>The main points are as follows:<BR>There is a correlation between the initial severity of symptoms and its duration. If the initial severity of illness is equal, we compared the illness scores using the same criteria, even if the starting day of medication is different. But the distinction of bacterial group is necessary. And in the mild cases, significant differences are prone to happen on evaluating the course.<BR>Difference by sex was not observed even if examined by several age groups.<BR>It is reasonable to devide the ages into four groups generally, 0-1, 2-15, 16-60 and >61. But because 0-1 and >61 groups follow quite different courses, it is better to exclude them from others on totaling.<BR>The influence of sensitivity of bacteria to antibiotics on the clinical course is not so marked, but is sometimes significant in the severe cases of Flexner in childhood.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 52 (12), 521-527, 1978

    一般社団法人 日本感染症学会

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