Clinical Evaluation of CLINORIL Tablets in Acute Upper Respiratory Tract Infections

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Other Title
  • 急性上気道炎に対するクリノリル錠の臨床治験
  • 急性上気道炎に対するクリノリル錠の臨床治療
  • キュウセイ ジョウキドウエン ニ タイスル クリノリルジョウ ノ リンショウ

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Abstract

The therapeutic effectiveness, safety and usefulness of CLINORIL (generic name: sulindac), a nonsteroidal anti inflammatory/analgesic agent, were evaluated in 72 patients with acute upper respiratory tract infections by an open trial.<BR>The patients were administered of CLINORIL in a daily dose of 300mg given in b.i.d. for 4 days. The study period was from November, 1981 to January, 1982. As for the effectiveness a slight to marked improvement in pain symptoms (pharynx, swallowing, joint and muscle pain and headache) was attained in 62.2-75.0% on the 3rd day and in 69.2-92.5% on the 5th day. Antipyretic effect was showen in all the 25 patients with fever on the 3rd day. On the other hand, the improvement of fatigue and respiratory symptoms was poor being 29.4-55.6% throughout an observation period of 5 days. Symptoms of local inflammation, namely, redness and swelling of the pharynx, and the tonsil were improved in 52.8-65.0% on the 3rd day, likewise in 72.4-100% on the 5the day. Only 2 patients experienced adverse reactions of stomach discomfort.<BR>Doctor's overall evalution on the usefulness of CLINORIL revealed that the treatment was quite useful in 19 (26.4%) of the 72 patients, moderately useful in 26 (36.1%), slightly useful in 22 (30.6%), ambiguous in 5 (6.9%), namely, of the 72 patients received CLINORIL those rated as slightly to quite useful were 67 (93.1%).

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 56 (12), 1186-1195, 1982

    The Japanese Association for Infectious Diseases

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