Severe Falciparum Malaria with Prolonged Hemolytic Anemia after Successful Treatment with Intravenous Artesunate

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  • ITODA Ichiro
    Department of Infectious Diseases, Tokyo Women's Medical University
  • YASUNAMI Takeshi
    Department of Infectious Diseases, Tokyo Women's Medical University
  • KIKUCHI Ken
    Department of Infectious Diseases, Tokyo Women's Medical University
  • YAMAURA Hisashi
    Department of Infectious Diseases, Tokyo Women's Medical University
  • TOTSUKA Kyoichi
    Department of Infectious Diseases, Tokyo Women's Medical University
  • YOSHINAGA Kentaro
    Department of Hematology, Tokyo Women's Medical University
  • TERAMURA Masanao
    Department of Hematology, Tokyo Women's Medical University
  • MIZOGUCHI Hideaki
    Department of Hematology, Tokyo Women's Medical University
  • HATABU Toshimitsu
    Department of Appropriate Technology Development and Transfer, Research Institute, Intemational Medical Center of Japan
  • KANO Shigeyuki
    Department of Appropriate Technology Development and Transfer, Research Institute, Intemational Medical Center of Japan

Bibliographic Information

Other Title
  • アーテスネート静注剤が著効したものの溶血性貧血が遷延した重症熱帯熱マラリアの1例
  • 臨床 アーテスネート静注剤が著効したものの溶血性貧血が遷延した重症熱帯熱マラリアの1例
  • リンショウ アーテスネート ジョウチュウザイ ガ チョコウ シタ モノ ノ ヨウケツセイ ヒンケツ ガ センエン シタ ジュウショウ ネッタイ ネツ マラリア ノ 1レイ

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Abstract

We report a 68-year-old woman with severe falciparum malaria contracted in Tanzania. She presented high parasitemia and was treated successfully with intravenous artesunate, a qinghaosu derivative, and aggressive supportive therapy. She developed hemolytic anemia and jaundice on day 11 and blood transfusion was required. This case illustrates that intravenous artesunate has excellent antimalarial activity with rapid efficacy and that no severe adverse effect but conventional aggressive supportive therapy is still important in the treatment of severe falciparum malaria.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 76 (8), 600-603, 2002

    The Japanese Association for Infectious Diseases

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