Intravenous Minocycline and Levofloxacin for Treatment of Two Cases of Japanese Spotted Fever

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  • SATO Akihiro
    Department of Infectious Diseases, Tokyo Medical University Hachioji Medical Center Department of Infection Prevention and Control, Tokyo Medical UniversityHospital
  • NAKAMURA Itaru
    Department of Infection Prevention and Control, Tokyo Medical UniversityHospital
  • IKEDA Hideki
    Department of Internal Medicine, Nagasaki Goto Chuoh Hospital
  • MIZUNO Yasutaka
    Department of Infection Prevention and Control, Tokyo Medical UniversityHospital
  • FUJII Takeshi
    Department of Infectious Diseases, Tokyo Medical University Hachioji Medical Center
  • MATSUMOTO Tetsuya
    Department of Microbiology, Tokyo Medical University
  • KANDA Tetsurou
    Department of Internal Medicine, Nagasaki Goto Chuoh Hospital

Bibliographic Information

Other Title
  • ミノサイクリン・レボフロキサシン注射薬併用が 著効した日本紅斑熱の2 例
  • 症例 ミノサイクリン・レボフロキサシン注射薬併用が著効した日本紅斑熱の2例
  • ショウレイ ミノサイクリン ・ レボフロキサシン チュウシャヤク ヘイヨウ ガ チョコウシタ ニホンコウ ハン ネツ ノ 2レイ

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Description

We report herein on two cases of Japanese spotted fever (JSF) treated with intravenous minocycline (MINO) and levofloxacin (LVFX). An 80 year-old woman (Case1) and a 63 year-old man (Case2) with high fever (＞39℃) and wide-spread skin erythema were admitted because they were suspected of having developed JSF. After admission, we treated them with intravenous MINO and LVFX. The patientsʼfevers were resolved within 36 hours after antibiotics. They were diagnosed as having JSF based on the serological test,and Rickettsia japonica was detected from the genetic findings (PCR analysis from eschar) only in case 1. In the treatment of fulminant JSF (body temperature＞39℃) the prompt administration of a combination of tetracycline and new quinolone has been recommended. The number of cases of JSF and its endemic area are gradually increasing in Japan. As for new quinolones, ciprofloxacin and tosufloxacin have been used against to JSF in Japan, but LVFX may become a new option.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 89 (5), 597-600, 2015

    The Japanese Association for Infectious Diseases

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