PI3K-AKT Network Roles in Infectious Diseases

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  • NOGUCHI Masayuki
    Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University
  • KINOWAKI Keiichi
    Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University

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Other Title
  • 感染症におけるPI3K-AKTシグナル伝達の意義
  • カンセンショウ ニ オケル PI3K AKT シグナル デンタツ ノ イギ

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Abstract

The PI3K-Akt network, which is activated by cytokines or growth factors, mediates intracellular signalsto regulate a variety of cellular responses, including antiapoptosis, proliferation, cell cycling, protein synthesis, glucose metabolism, and telomere activity. Genomic mutations, alterations of the PI3K-Akt regulatorynetwork, underlie such diseases as cancer, glucose intolerance (diabetes mellitus), schizophrenia, and/orautoimmune diseases. In addition to direct tumorigenesis involvement by genetically altering human cancer, the PI3K-Akt network underlies the clinical manifestation of different stages of tumorigenic viral infection, such as latent and chronic infection, and malignant transformation of Epstein-Barr, hepatitis C, hepatitis B, and human immunodeficiency virus (HIV) viruses. We summarize updated knowledge on the PI3K-AKTnetwork underlying different phathological viral and/or bacterial infections. Antiviral activity engenderedby suppressing of PI3K-Akt activity, rather than directly targeting anticancer activity via oncogenes, maythus open up ways to prevent malignant transformation by tumorigenic viral infection.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 82 (3), 161-167, 2008

    The Japanese Association for Infectious Diseases

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