Childhood Bacterial Meningitis Trends in Japan from 2005 to 2006

DOI Web Site 12 Citations 19 References
  • SUNAKAWA Keisuke
    Kitasato Institute for Life Science & Graduate School of Infection Control Science, Kitasato University
  • UBUKATA Kimiko
    Kitasato Institute for Life Science & Graduate School of Infection Control Science, Kitasato University
  • CHIBA Nahoko
    Kitasato Institute for Life Science & Graduate School of Infection Control Science, Kitasato University
  • HASEGAWA Keiko
    Kitasato Institute for Life Science & Graduate School of Infection Control Science, Kitasato University
  • NONOYAMA Masato
    Department of Pediatrics, Ebina General Hospital
  • IWATA Satoshi
    Department of Pediatrics, National Hospital Organization Tokyo Medical Center
  • AKITA Hironobu
    Department of Pediatrics, St. Marianna University School of Medicine Yokohama City Seibu Hospital
  • SATO Yoshitake
    Department of Pediatrics, Fuji Heavy Industries LTD. Health Insurance Society General Ota Hospital

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Other Title
  • 本邦における小児細菌性髄膜炎の動向 (2005～2006)
  • ホンポウ ニ オケル ショウニ サイキンセイ ズイマクエン ノ ドウコウ 2005 2006

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Abstract

We surveyed pediatric bacterial meningitis epidemiology from January 2005 to December 2006 in Ja-pan, with the following results. Bacterial meningitis cases numbered 246 -138 boys and 108 girls-, equivalentto 1.7-1.72 children of 1, 000 hospitalized in pediatrics per year. The age distribution for infection was highestin those under 1 year of age and decreased with increasing age. Haemophilus influenzae was the most com-mon infection causing the pathogen, followed by Streptococcus pneumoniae, group B streptococcus, and Escherichia coil. The relationship between causative pathogens and age distribution was as follows: group B streptococcus and E. coli were major pathogens in patients under 4 months old and H. influenzae and S. pneumoniae in those over 4 months old. Susceptibility tests at individual facilities showed 59.3% of H. influenzae isolates and 69.3% of S. pneumoniae isolates in 2004 to be drug-resistant.<BR>Ampicillin and cephem antibiotics are effective against GBS, E. coli, and Listeria, so combined of ampicil-lin and cephem antibiotics are used as first-line antibiotics in many facilities in patients under 4 month oldand combined of carbapenem antibiotics effective against PRSP and cephem effective against H. influenzae were the first choice against childhood bacterial meningitis in patients over 4 month old.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 82 (3), 187-197, 2008

    The Japanese Association for Infectious Diseases

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