Hemagglutination Titer of Gamma-Globulin Preparations for Intravenous Use Against OEP (original Endotoxin Protein), Protease and Elastase of <I>Pseudomonas Aeruginosa</I>

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  • YAMASHITA Naoya
    Department of Pediatrics, School of Medicine, Keio Unvieraity Department of Pediatrics, Kitasato Institute Hospital
  • JOZAKI Keiji
    Department of Pediatrics, School of Medicine, Keio Unvieraity
  • IWASAKI Yukio
    Department of Pediatrics, School of Medicine, Keio Unvieraity
  • IWATA Satoshi
    Department of Pediatrics, School of Medicine, Keio Unvieraity
  • SUNAKAWA Keisuke
    Department of Pediatrics, School of Medicine, Keio Unvieraity

Bibliographic Information

Other Title
  • 市販静注用ガンマ・グロブリン製剤の緑膿菌内毒素蛋白部分 (OEP), Protease, Elastase羊赤血球凝集素価
  • シハン ジョウチュウヨウ ガンマ ・ グロブリン セイザイ ノ リョクノウキン ナイドクソ タンパク ブブン(OEP),Protease,Elastase ヒツジ セッケッキュウ ギョウシュウソカ
  • Hemagglutination Titer of Gamma-Globulin Preparations for Intravenous Use Against OEP (original Endotoxin Protein), Protease and Elastase of Pseudomonas Aeruginosa

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Abstract

Using formalinized sheep erythrocytes treated with tannic acid and coated with OEP (protein moiety of endotoxin), protease and elastase of Pseudomonas aeruginosa, passive hemagglutination titer was measured on three kinds of gamma-globulin preparations (13 lots from each maker).<BR>67%(26/39) of gamma-globuin preparations had detectable HA antibody against OEP. 97%(38/39) had HA antibody against protease, and 92%(33/36) against elastase. No significant difference was found between mean value of OEP-HA of pepsin treated and polyethyleneglycol (PEG) treated preparations. Sulfonated preparations had a tendency to have a low OEP-HA and the difference was significant (p<0.05) compared with pepsin treated preparations. In the case of protease-HA, pepsin treated treated preparation had the highest mean value and sulfonated preparation had lowest mean value. The difference was significant. No difference in elastase HA was noted among all three gamma-globulin preparations.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 55 (9), 637-641, 1981

    The Japanese Association for Infectious Diseases

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