Metastatic Fibrosarcoma of the Brain: Transformation From Conventional to Epithelioid Form-Case Report-

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  • ERGUVAN-ÖNAL Rezzan
    Department of Pathology, Inönü University School of Medicine
  • ÖNAL Çagatay
    Department of Neurosurgery, Inönü University School of Medicine
  • GÜRLEK Ali
    Department of Plastic and Reconstructive Surgery, Inönü University School of Medicine
  • ALKAN Alpay
    Department of Radiology, Inönü University School of Medicine
  • ERKAL Haldun Sükrü
    Department of Radiation Oncology, Inönü University School of Medicine
  • MIZRAK Bülent
    Department of Pathology, Inönü University School of Medicine

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  • —Case Report—

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A 45-year-old woman presented with an extremely rare metastatic fibrosarcoma of the brain manifesting as persistent headache. She had undergone surgery for a fibrosarcoma of the soft tissue of the thigh 2 months earlier. She had a history of previous surgery and radiotherapy for this tumor. She was somnolent with papilledema and left hemiparesis. Magnetic resonance imaging of the brain revealed a right frontal lesion with mass effect and heterogeneous enhancement. Computed tomography and scintigraphy showed multiple metastatic lesions of the lung. Right frontal craniotomy was performed for gross total removal of the yellowish-white tumor. Histological examination showed signs of epithelioid transformation based on positive staining for epithelial membrane antigen compared to the primary tumor. Postoperatively the patient was alert and the left hemiparesis improved. She refused radiotherapy or chemotherapy. Follow-up computed tomography showed multiple intracranial metastases. She died 5 months after the surgery.<br>

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