Functional Analysis of trk Proto-oncogene Product in Medulloblastoma Cells
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- KOKUNAI Takashi
- Department of Neurosurgery, Kobe University School of Medicine
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- SAWA Hideki
- Department of Neurosurgery, Kobe University School of Medicine
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- TAMAKI Norihiko
- Department of Neurosurgery, Kobe University School of Medicine
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説明
MED-L cells with the 75 kd low-affinity nerve growth factor receptor (p75NGFR) and MED-H cells with the proto-oncogene tropomyosin receptor kinase product (p140trk) were isolated selectively from a parent MED-3 cell line derived from cerebellar medulloblastoma by panning, and the interaction of nerve growth factor (NGF) with these cell lines was analyzed. NGF treatment induced neuronal differentiation, growth inhibition, and tyrosine phosphorylation of p140trk in MED-H cells, but not in MED-L cells. Medulloblastoma cells express the functional NGFR, p140trk, which regulates their differentiation and growth.
収録刊行物
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 36 (11), 796-804, 1996
一般社団法人 日本脳神経外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282680026490624
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- NII論文ID
- 110002278855
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- NII書誌ID
- AN00358613
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- ISSN
- 13498029
- 04708105
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- PubMed
- 9420431
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
