Toxoplasmic Encephalitis and Cytomegaloviral Retinitis in a Non-AIDS Patient with Chronic Renal Failure Undergoing Corticosteroid Therapy

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  • KATO Tetsuro
    Department of Infection Control and Prevention, The Jikei University School of Medicine
  • SATO Fumiya
    Department of Infection Control and Prevention, The Jikei University School of Medicine
  • SAKAMOTO Mitsuo
    Department of Infection Control and Prevention, The Jikei University School of Medicine
  • YOSHIKAWA Koji
    Department of Infection Control and Prevention, The Jikei University School of Medicine
  • YOSHIDA Masaki
    Department of Infection Control and Prevention, The Jikei University School of Medicine
  • ONODERA Shouichi
    Department of Infection Control and Prevention, The Jikei University School of Medicine

Bibliographic Information

Other Title
  • ステロイド投与中の慢性腎不全患者に発症し，サイトメガロウイルス網膜炎を併発した非AIDS トキソプラズマ脳炎の1 例
  • 症例 ステロイド投与中の慢性腎不全患者に発症し,サイトメガロウイルス網膜炎を併発した非AIDSトキソプラズマ脳炎の1例
  • ショウレイ ステロイド トウヨ チュウ ノ マンセイ ジンフゼン カンジャ ニ ハッショウ シ サイトメガロウイルス モウマクエン オ ヘイハツ シタ ヒAIDS トキソプラズマ ノウエン ノ 1レイ

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Abstract

We report a rare case of toxoplasmic encephalitis in a non-AIDS patient. A 62-year-old man undergoing hemodialysis for seven months and corticosteroid therapy for rapidly progressive glomerulonephritis and admitted for generalized convulsions was found in cranial magnetic resonance imaging (MRI) to have multiple ring-enhanced lesions. Antibodies against Toxoplasma gondii, and in Sabin-Feldman dye test were extremely high, yielding a diagnosis of toxoplasmic encephalitis. He was also diagnosed as having cytomegaloviral retinitis. Anti-HIV antibody was negative. Treatment with pyrimethamine and clindamycin was effective and intracerebral lesions disappeared. Physicians encounting a similar situation should consider toxoplasmic encephalitis as a differential diagnosis, even in non-HIV patients, and implement confirmational examination.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 83 (5), 534-537, 2009

    The Japanese Association for Infectious Diseases

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