Long Term Observation for Immunogenecity of Hepatitis B Vaccine in Infants and Adults

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  • HAYASHI Jun
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • KASHIWAGI Seizabro
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • NOMURA Hideyuki
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • KAJIYAMA Wataru
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • IKEMATSU Hideyuki
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • SHINGU Toshimitsu
    Department of Pediatrics, Prefectual Nichinan Hospital

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Other Title
  • 乳幼児および成人におけるHBワクチン接種成績の長期観察
  • ニュウヨウジ オヨビ セイジン ニ オケル HB ワクチン セッシュ セイセキ

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Abstract

In order to investigate how long the antibody to hepatitis surface antigen (anti-HBs) remains in the blood stream after a hepatitis B vaccine (HB vaccine) is given, a total number of 525 vaccinees were followed up from 19 to 36 months after the first injection. 261 infants (137 males and 124 females) and 264 adults (61 male and 203 females), who were negative for HBV markers such as HBsAg, antii-HBs and anti-HBc were immunized with 10 mcg for infants and 20 mcg for adults. Four kinds of vaccine were used in the study. Thirty-four infants who either had no anti-HBs response or who had an anti-HBs response which later disappeared were given one or two more doses of 10 mcg. The following results were obtained.<BR>1) The anti-HBs seroconversion rate after three vaccinations was 83.5% in 9 (after the first vaccination), 76.2% in 19 months and 60.9% in 36 months.<BR>2) The anti-HBs seroconversion rate was higher in females than in males.3) The anti-HBs seroconversion rate was higher in the age groups 4-5 years, 20-29 years and 30-39 years than in above 50 years.<BR>4) The anti-HBs seroconversion rate after 4 or 5 vaccinations was 44% in 36 months.<BR>5) The titer of anti-HBs was 27.2 in 9 months, 25.6 in 19 months and 25 in 36 months.<BR>6) The main side effects were soreness at the injection site (15.0%) and general fatigue or malaise (17.7%). But most of the side effects were mild and disappered soon without any treatment.<BR>We think that HB vaccine is safe and effective for the prevention of hepatitis B infection.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 60 (7), 659-665, 1986

    The Japanese Association for Infectious Diseases

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