Examination of Metallo-β-lactamase-producing Different Types of <i>Serratia marcescens</i> Detected in the Same Patient

DOI Web Site 28 References
  • ITO Takamitsu
    Laboratory of Microbiology, Kochi Prefectural Hata Kenmin Hospital Mitsubishi Chemical Medience Corporation
  • FUKUI Yasuo
    Department of Infection Diseases, Kochi Health Sciences Center
  • ONO Noriaki
    Department of Urology, Kochi Health Sciences Center
  • IKEDA Fumiaki
    Mitsubishi Chemical Medience Corporation
  • KANAYAMA Akiko
    Department of Infection Control and Prevention, Faculty of Nursing, Toho University
  • KOBAYASHI Intetsu
    Department of Infection Control and Prevention, Faculty of Nursing, Toho University

Bibliographic Information

Other Title
  • 同一患者から検出された <i>Serratia marcescens</i> の metallo-β-lactamase 産生株および非産生株に関する検討
  • 同一患者から検出されたSerratia marcescensのmetallo-β-lactamase産生株および非産生株に関する検討
  • ドウイツ カンジャ カラ ケンシュツ サレタ Serratia marcescens ノ metallo-v-lactamase サンセイカブ オヨビ ヒサンセイカブ ニ カンスル ケントウ

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Description

Metallo-β-lactamase（MBL）producing Serratia marcescens isolate was recovered from a study patient in September, 2007 in whom MBL non-producing S. marcescens had been isolated 2 months previously. Two S. marcescens isolates recovered from the study patient showed the same pulsed-field gel electrophoresis （PFGE）pattern. Seven S. marcescens isolates were recovered from other patients in our hospital during August, 2007 and November, 2007. Five of the seven isolates produced MBL. All of the MBL-producing isolates showed the same PFGE pattern and harbored plasmids of the same size and blaIMP genes. The blaIMP genes were easily transferred to Escherichia coli DH5α by transformation of a plasmid purified from the MBL-producing isolate. Those transformation experiments suggested that blaIMP genes were encoded by the plasmid. From these observations, it was speculated that the MBL non-producing S. marcescens isolate recovered from the study patient had acquired the plasmid which encoded blaIMP genes and a monoclone of MBL-producing S. marcescens spread horizontally in our hospital.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 87 (2), 189-194, 2013

    The Japanese Association for Infectious Diseases

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