Clinical Characterization of <I>bla</I><SUB>IMP</SUB> Positive Gram-negative Rods Isolated Cases

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  • NAKANO Tetsuji
    Second Department of Internal Medicine, Oita Medical University Hospital
  • HIRAMATSU Kazufumi
    Clinical Laboratory Center, Oita Medical University Hospital
  • HIRATA Norio
    Second Department of Internal Medicine, Oita Medical University Hospital
  • MURAKAMI Junko
    Second Department of Internal Medicine, Oita Medical University Hospital
  • ICHIMIYA Tomoku
    Second Department of Internal Medicine, Oita Medical University Hospital
  • TOKIMATSU Issei
    Second Department of Internal Medicine, Oita Medical University Hospital
  • YAMAGATA Eiji
    Second Department of Internal Medicine, Oita Medical University Hospital
  • YAMAKAMI Yuriko
    Second Department of Internal Medicine, Oita Medical University Hospital
  • YAMASAKI Tohru
    Second Department of Internal Medicine, Oita Medical University Hospital
  • NAGAI Hiroyuki
    Second Department of Internal Medicine, Oita Medical University Hospital
  • KADOTA Jun-ichi
    Second Department of Internal Medicine, Oita Medical University Hospital
  • NASU Masaru
    Second Department of Internal Medicine, Oita Medical University Hospital
  • NAKANO Tadao
    Clinical Laboratory Center, Oita Medical University Hospital
  • SAIKAWA Tetsunori
    Clinical Laboratory Center, Oita Medical University Hospital

Bibliographic Information

Other Title
  • メタロβ-ラクタマーゼ遺伝子<I>bla</I><SUB>IMP</SUB>陽性グラム陰性桿菌検出症例の臨床的検討
  • メタロβ-ラクタマーゼ遺伝子blaIMP陽性グラム陰性桿菌検出症例の臨床的検討
  • メタロ ベータ ラクタマーゼ イデンシ blaIMP ヨウセイ グラム インセイカンキン ケンシュツ ショウレイ ノ リンショウテキ ケントウ
  • Clinical Characterization of blaIMP Positive Gram-negative Rods Isolated Cases

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Abstract

We detected the metallo-β-lactamase gene blaIMP positive strains of the gram-negative rods (GNR) isolated in Oita Medical University Hospital between 1993 and 1999 and studied the clinical characteristics of patients infected or colonized with blaIMP positive GNR. 25 strains (20 Pseudomonas aeruginosa and 5 Serratia marcescens) were detected and most of them were isolated from urinary samples after 1997. In the studies of antimicrobial susceptibility, some strains had sensitivity to aztreonum or imipenem although most of the strains showed multidrug resistance.<BR>When blaIMP positive GNR were isolated from patients, these strains were thought to have caused infection in 88% of the patients. About half of the patients were over 65 years old and had malignant diseases. Most of the patients had inserted urinary tract catheters, intratracheal tube or intravernous catheters. It was suggested that the insertion of the catheters were related to infection of blaIMP positive GNRs. Two patients were not treated with any antibiotics before the isolation of Ham, positive GNRs although more than half of the patients were administered carbapenems and cephems. Most of strains were isolated in the same department and showed the same genotype by pulsed field gel electrophoresis.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 75 (11), 946-954, 2001

    The Japanese Association for Infectious Diseases

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