<I>Emm</I> Typing by Genetic Identification of <I>Streptococcus dysgalactiae</I> subsp. <I>equisimilis</I> and Susceptibility to Oral Antibiotics

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  • SUNAOSHI Katsuhiko
    Department of Clinical Microbiology, Saitama Institute of Public Health Laboratory of Infectious Agents Surveillance, Kitasato Institute for Life Sciences, Kitasato University
  • ABURAHASHI Hiromi
    Graduate School of Infection Control Sciences Kitasato University
  • KOBAYASHI Reiko
    Laboratory of Infectious Agents Surveillance, Kitasato Institute for Life Sciences, Kitasato University
  • YAMAMOTO Yoshitaka
    Division of Infection Control, Department of Medical Safety Administration, Dokkyo University School of Medicine Hospital
  • OKUZUMI Katsuko
    Division of Infection Control, Department of Medical Safety Administration, Dokkyo University School of Medicine Hospital
  • YOSHIDA Atsushi
    Division of Infection Control, Department of Medical Safety Administration, Dokkyo University School of Medicine Hospital
  • MISAWA Yoshiki
    Department of Infection Control and Prevention, University of Tokyo Hospital
  • ADACHI Keiko
    Laboratory Medicine, Tokyo Metropolitan Geriatric Medical Center
  • UBUKATA Kimiko
    Graduate School of Infection Control Sciences Kitasato University Laboratory of Infectious Agents Surveillance, Kitasato Institute for Life Sciences, Kitasato University

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Other Title
  • <I>Streptococcus dysgalactiae</I> subsp. <I>equisimilis</I>の遺伝子解析による<I>emm</I>型別と経口抗菌薬感受性
  • Streptococcus dysgalactiae subsp. equisimilisの遺伝子解析によるemm型別と経口抗菌薬感受性
  • Streptococcus dysgalactiae subsp equisimilis ノ イデンシ カイセキ ニ ヨル emm ガタベツ ト ケイコウ コウキンヤク カンジュセイ
  • Emm Typing by Genetic Identification of Streptococcus dysgalactiae subsp. equisimilis and Susceptibility to Oral Antibiotics

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Abstract

A total of 593 β-hemolytic streptococci belonging to Lancefield group A (GAS), group C (GCS) or group G (GGS) according to agglutination tests were collected from 11 medical institutions between September 2003 and October 2005. In total, 128 strains were identified as Streptococcus dysgalactiae subsp. equisimilis (S. equisimilis ) using physiological tests. Of these strains, 5 strains were agglutinated to Lancefield group A, 17 strains to group C, and 106 strains to group G. Most of these strains were largely isolated from clinical specimens collected from young patients with respiratory infections and middle-aged patients (in their 40s); most of the strains were isolated from blood, atretic pus, or joint fluid. Genetic analysis of the emm gene encoding the M protein revealed that these strains could be classified into 27 types. Also, many emm types were found in strains isolated from normally aseptic clinical specimens. In addition, all strains tested had slo, sagA, and skcg genes, which contributed to their virulence. The susceptibility of the strains to oral penicillin and cephalosporin antibiotics was excellent, with MICs ranging from 0.016 to 0.031mg/mL. In contrast, strains carrying the macrolide resistant elements of the ermA, ermB, and mefA genes and strains showing a high resistance to levofloxacin were also confirmed in this study. These results suggest that 13-hemolytic streptococci, except for S. pyogenes and S. agalactiae, should be reconsidered as a causative pathogen in streptococcal infections.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 80 (5), 488-495, 2006

    The Japanese Association for Infectious Diseases

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