Studies of Treatment for <I>Haemophilus influenzae</I> Type b Meningitis in Children

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  • HOSHINO Tadashi
    Department of Pediatrics, Chiba University Graduate School of Medicine Division of Infectious Diseases, Chiba Children's Hospital
  • ISHIWADA Naruhiko
    Department of Pediatrics, Chiba University Graduate School of Medicine
  • ABE Katsuaki
    Department of Pediatrics, Chiba University Graduate School of Medicine Division of Infectious Diseases, Chiba Children's Hospital
  • OGITA Junko
    Department of Pediatrics, Chiba University Graduate School of Medicine
  • FUKASAWA Chie
    Department of Pediatrics, Chiba University Graduate School of Medicine
  • SUDO Fusayo
    Department of Pediatrics, Chiba University Graduate School of Medicine
  • INAMI Yukiko
    Department of Pediatrics, Chiba University Graduate School of Medicine
  • HISHIKI Haruka
    Department of Pediatrics, Chiba University Graduate School of Medicine
  • AIZAWA Jiro
    Department of Pediatrics, Chiba University Graduate School of Medicine Division of Pediatrics, Chiba Municipal Aoba Hospital
  • ISHIKAWA Nobuyasu
    Division of Pediatrics, Chiba Municipal Aoba Hospital
  • KUROSAKI Tomomichi
    Division of Pediatrics, Chiba Municipal Kaihin Hospital
  • NAKAMURA Akira
    Division of Infectious Diseases, Chiba Children's Hospital Department of Health and Welfare, Chiba Prefectural Government
  • KOHNO Yoichi
    Department of Pediatrics, Chiba University Graduate School of Medicine

Bibliographic Information

Other Title
  • 小児インフルエンザ菌性髄膜炎の抗菌療法に関する検討
  • ショウニ インフルエンザキンセイ ズイマクエン ノ コウキン リョウホウ ニ カンスル ケントウ
  • Studies of Treatment for Haemophilus influenzae Type b Meningitis in Children

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Abstract

We summarize 41 cases of bacterial meningitis in the last 11 years caused by Haemophilus influenzae. All isolates were serotype b strain (Hib). Initial chemotherapy was started with ceftriaxone (CTRX) in 22 cases, ampicillin plus cefotaxime (CTX) in 9, CTRX plus panipenem/betamipron in 5, and CTX in 2. Some 31 cases were treated mainly with CTRX. Although therapeutic antibiotics showed good susceptibility for isolates, 8 complicated cases (19.5%) occurred. Sequalae were observed in 7 (17.1%) but none were fatal. Five strains with elevated MIC of CTX (0.12 to 1 μg /mL) recovered after 2001, and 3 of 5 strains also showed elevated MIC of CTRX (0.12 to 0.5 μg /mL), but all were cured completely with CTRX At present, no treatment failures due to antibiotic resistance have been observed, and CTRX remains suitable as initial therapy for Hib meningitis. A decline in susceptibility for third-generation cephalosporin against β -lactamase-nonproducing ampicillin-resistant H. influenzae is emerging, however, so it will be necessary to consider combination therapy with CTRX given the foreseeable trend in MICs.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 81 (1), 51-58, 2007

    The Japanese Association for Infectious Diseases

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