呼吸器感染症に対するSF-837の二重盲検試験

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タイトル別名
  • Double-Blind Trial of SF-837 in the Treatment of Respiratory Infections
  • コキュウキ カンセンショウ ニ タイスル SF-837 ノ ニジュウ モウケンシケン

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説明

SF-837 is a new macrolide antibiotic isolated from the culture broth of Streptomyces mycarofaciens nov. sp.<BR>Results of the fundamental studies reported so far indicate that its antimicrobial antivity, absorption, distribution and excretion are quite similar to those of other macrolides.<BR>This paper describes the clinical results of comparative double-blind studies on SF-837 and kitasamycin in the treatment of respiratory infections such as acute tonsillitis, acute bronchitis and bacterial pneumonia.<BR>The satisfactory results were obtained in 61 paptients of 73 in the SF-837 group (83.6%) and in 62 patients of 77 in the kitasamycin group (80.5%). Statistical analysis of the obtained results revealed that there was no significant difference between the two groups. (p<0.05;χ2=0.356)<BR>Generally, the most frequent side effect of macrolide antibiotics is gastrointestinal disturbance, the patients, therefore, were observed with a special attention to this point.<BR>As a result, gastrointestinal disturbances were observed in 6 out of 77 cases in the kitasamycin group and only one out of 73 cases in the SF-837 group.<BR>From the above results, SF-837 can be considered to be an effective antibiotic comparative to kitasamycin.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 46 (9), 332-341, 1972

    一般社団法人 日本感染症学会

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