Relationship between ABO Histo-blood Group Type and an Outbreak of Norovirus Gastroenteritis among Primary and Junior High School Students
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- MIYOSHI Masahiro
- Hokkaido Institute of Public Health
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- YOSHIZUMI Shima
- Hokkaido Institute of Public Health
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- SATO Chiaki
- Hokkaido Institute of Public Health
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- OKUI Toyo
- Hokkaido Institute of Public Health
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- OGAWA Hiroshi
- Hokkaido Institute of Public Health
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- HONMA Hiroshi
- Hokkaido Institute of Public Health
Bibliographic Information
- Other Title
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- 小中学校で発生した集団食中毒におけるノロウイルスとABO式血液型の関係
- Results of Questionnaire-based Study
- アンケートに基づく実態調査
Description
Noroviruses are common causative agents of epidemic gastroenteritis in humans. Recent studies showed that human susceptibility to noroviruses was associated with ABO histo-blood group type. It was also observed that various degrees of susceptibility were exhibited by different norovirus strains. In January 2003, an outbreak of acute gastroenteritis including 661 affected primary and junior high school students occurred through lunch bread contaminated with norovirus in Hokkaido, Japan. To clarify the relationship between ABO histo-blood group type and the norovirus infection, we performed a written questionnaire to schoolchildren about the consumption of the bread, onset of symptoms and person-to-person transmission in their household. Questionnaires were returned from 722 schoolchildren(response rate. 65.8%), of whom 55.3% suffered gastroenteritis. As a result of this survey, it was found that schoolchildren with blood group type A(71.1%, 133/187)were more susceptible to the norovirus infection, whereas, schoolchildren with blood group type AB (55.3%, 26/47) were less affected [P (Z0) <0.025]. In addition, the presumptive prevalence rate of personto-person transmission in each household indicated that schoolchildren with blood group type AB (19.2%, 5/26) had a lower risk of infection than those with blood group type A or O [A: 41.4%, 55/133 O: 39.5%, 49/124(unknown for one case)] [P(Z0)<0.025].Our findings suggested that persons with blood group type AB were less affected by the norovirus infection in this outbreak.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 79 (9), 664-671, 2005
The Japanese Association for Infectious Diseases
