A Case of Acute Respiratory Distress Syndrome (ARDS) Accompanied with Influenza (H1N1) 2009 Successfully Treated with Polymyxin B-immobilized Fiber Column-direct Hemoperfusion (PMX-DHP)

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  • NAKANO Mayuri
    Department of Internal Medicine, JA Kochi Hospital Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital
  • YOSHIDA Seiji
    Department of Internal Medicine, JA Kochi Hospital
  • NAKAYAMA Tadashi
    Department of Internal Medicine, JA Kochi Hospital
  • OGUSHI Fumitaka
    Department of Respiratory Medicine, National Hospital Organization Kochi National Hospital
  • HANIBUCHI Masaki
    Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital
  • NISHIOKA Yasuhiko
    Department of Respiratory Medicine and Rheumatology, Tokushima University Hospital

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Other Title
  • インフルエンザ（H1N1）2009 に伴うARDS に PMX-DHP 療法が奏効した1 例
  • 症例 インフルエンザ(H1N1)2009に伴うARDSにPMX-DHP療法が奏効した1例
  • ショウレイ インフルエンザ(H1N1)2009 ニ トモナウ ARDS ニ PMX-DHP リョウホウ ガ ソウコウ シタ 1レイ

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Abstract

A 51-year-old man was admitted to our hospital because of fever and diarrhea. Chest X-ray revealed consolidation in the left lower lung field. Ceftriaxone and minocycline were given empirically, under the suspicion of bacterial or atypical pneumonia. In spite of treatment with antibiotics, the disease rapidly progressed to systemic inflammatory response syndrome. The diagnosis of acute respiratory distress syndrome (ARDS) accompanied with influenza (H1N1) 2009 was made because of positive findings of real-time polymerase chain reaction. While multidisciplinary treatment was performed, his condition was further deteriorated suggesting the excessive pro-inflammatory mediators. To remove them, we conducted polymyxin-B immobilized column-direct hemoperfusion (PMX-DHP), and his general condition recovered successfully. PMX-DHP may be a useful treatment choice for ARDS accompanied with influenza.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 89 (3), 416-421, 2015

    The Japanese Association for Infectious Diseases

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