A Case of Osteomyelitis with a Granulomatous Lesion Caused by <i>Salmonella </i>Infantis

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  • 肉芽腫病変を呈した<i>Salmonella </i>Infantis 骨髄炎の1 例
  • 症例 肉芽腫病変を呈したSalmonella Infantis骨髄炎の1例
  • ショウレイ ニクガシュ ビョウヘン オ テイシタ Salmonella Infantis コツズイエン ノ 1レイ

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Abstract

We report herein on a case of osteomyelitis with a granulomatous lesion caused by Salmonella enterica subsp. enterica serovar Infantis (Salmonella Infantis). A 30-year-old Japanese man presenting with a 3-week history of left ankle pain was suspected to have either a tumor or osteomyelitis, on the basis of imaging study findings. He underwent a surgical resection of the lesion. Histopathological examination revealed a granuloma. However, S. Infantis was cultured from the biopsy sample. Cefazolin was initially administered as empirical therapy. We switched the antibiotic to ampicillin on the basis of the anitibiotic-susceptibility test results. Six weeks after intravenous ampicillin therapy, we switched to oral ciprofloxacin. He has had no recurrence in the 3 years after treatment completion. Salmonella osteomyelitis is rare and this pathogen seldom causes a granulomatous lesion. According to the findings in our case, Salmonella spp. should be considered as one of the differential diagnoses for granulomatous lesions in the bone.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 89 (4), 476-480, 2015

    The Japanese Association for Infectious Diseases

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