Amino Acid Study of Cerebral Gliomas Using Positron Emission Tomography

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  • MINEURA Katsuyoshi
    Neurosurgical Service, Akita University School of Medicine
  • SASAJIMA Toshio
    Neurosurgical Service, Akita University School of Medicine
  • SUDA Yoshitaka
    Neurosurgical Service, Akita University School of Medicine
  • KOWADA Masayoshi
    Neurosurgical Service, Akita University School of Medicine
  • SHISHIDO Fumio
    Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita
  • UEMURA Kazuo
    Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita

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  • —Analysis of (<SUP>11</SUP>C-methyl)-L-methionine Uptake Index—

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Sixteen patients with gliomas (7 low grade, 9 high grade) were examined using positron emission tomography (PET) with intravenous administration of 22.2 MBq/kg (0.6 mCi/kg) of (11C-methyl)-L-methionine (C-11 Met). The tracer uptake in regions of interest was calculated on PET images taken 45 minutes after injection; the uptake index was represented as a percentage of the total count in the arterial blood summed over 45 minutes. C-11 Met uptake indices in the tumors ranged from 0.020 to 0.041% with a mean of 0.032% for the low-grade gliomas and from 0.013 to 0.044% with a mean of 0.036% for the high-grade gliomas. These indices significantly increased as compared with those in the contralateral gray matter (0.008-0.032% with a mean of 0.023%; p < 0.01 vs. low-grade gliomas, p < 0.001 vs. high-grade gliomas). In the low-grade gliomas, C-11 Met PET images clearly depicted the existence and even the extent of the tumors, although x-ray computed tomography (CT) did not always distinguish tumoral lesions. In the high-grade gliomas, the areas of tracer accumulation regionally extended to peritumoral low density on CT scans, where malignant tumor cell infiltration was proved by operative and follow-up CT findings. C-11 Met may be a useful radiopharmaceutical for differential diagnosis of gliomas, and the accuracy of tumor localization will give us a better rationale in therapeutic strategies for surgery and radiation therapy of gliomas.

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