Treatment and Prognosis of Brain Metastases From Gynecological Cancers
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- OGAWA Kazuhiko
- Department of Radiology, University of the Ryukyus School of Medicine
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- YOSHII Yoshihiko
- Department of Neurosurgery, University of the Ryukyus School of Medicine
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- AOKI Yoichi
- Department of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
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- NAGAI Yutaka
- Department of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
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- TSUCHIDA Yukihiro
- Department of Neurosurgery, University of the Ryukyus School of Medicine
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- TOITA Takafumi
- Department of Radiology, University of the Ryukyus School of Medicine
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- KAKINOHANA Yasumasa
- Department of Radiology, University of the Ryukyus School of Medicine
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- TAMAKI Wakana
- Department of Radiology, University of the Ryukyus School of Medicine
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- IRAHA Shiro
- Department of Radiology, University of the Ryukyus School of Medicine
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- ADACHI Genki
- Department of Radiology, University of the Ryukyus School of Medicine
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- HIRAKAWA Makoto
- Department of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
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- KAMIYAMA Kazuya
- Department of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
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- INAMINE Morihiko
- Department of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
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- HYODO Akio
- Department of Neurosurgery, University of the Ryukyus School of Medicine
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- MURAYAMA Sadayuki
- Department of Radiology, University of the Ryukyus School of Medicine
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Abstract
Brain metastases from gynecological cancers were retrospectively investigated in 18 patients who were treated between 1985 and 2006. Six patients received surgical resection followed by radiotherapy, and 12 patients received only radiotherapy. The median survival for all patients was 4.1 months (range 0.7-48.2 months), and the actuarial survival rates were 11% at both 12 months and 24 months. Univariate analysis showed that treatment modality, extracranial disease status, total radiation dose, number of brain metastases, and Karnofsky performance status (KPS) all had statistically significant impacts on survival. Two patients survived for more than 2 years, and both had single brain metastasis, inactive extracranial disease, 90-100% KPS, and were treated with surgical resection followed by radiotherapy. Improvements in neurological symptoms were observed in 10 of the 12 patients treated with palliative radiotherapy, with median duration of 3.1 months (range 1.5-4.5 months). The prognoses for patients with brain metastases from gynecological cancers were generally poor, although selected patients may survive longer with intensive brain tumor treatment. Palliative radiotherapy was effective in improving the quality of the remaining life for patients with unfavorable prognoses.<br>
Journal
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 48 (2), 57-63, 2008
The Japan Neurosurgical Society
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Details
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- CRID
- 1390282680029558016
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- NII Article ID
- 110006596197
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- NII Book ID
- AN00358613
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- ISSN
- 13498029
- 04708105
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed