REFERENCE RANGES OF SERUM TOTAL AND FREE TESTOSTERONE IN JAPANESE MALE ADULTS

DOI PubMed 22 Citations 28 References Open Access
  • Iwamoto Teruaki
    Department of Urology, Center for Riproduductive Medicine, ST Marianna University School of Medicine
  • Yanase Toshihiko
    Deprtment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
  • Koh Eitetsu
    Department of Integrative Cancer Therapy and Urology, Kanazawa Univercity Graduate School of Medical Sciences
  • Horie Hitoshi
    Mitsubishi Kagaku Bio-Clinical Laboratories, INC.
  • Baba Katsuyuki
    Department of Urology, Center for Riproduductive Medicine, ST Marianna University School of Medicine
  • Namiki Mikio
    Department of Integrative Cancer Therapy and Urology, Kanazawa Univercity Graduate School of Medical Sciences
  • Nawata Hajime
    Deprtment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University

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  • 日本人成人男子の総テストステロン, 遊離テストステロンの基準値の設定

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(Purpose) To establish reference range of serum Total Testosterone (T-T) and Free Testosterone (F-T) in Japanese male adults.<br>(Subjects and Method) Among 1, 172 male adults, who daily lived their healthy life, 1, 143 subjects in the year range from 20 to 77 years old, who had serum LH concentration within its reference range (For 20-70years old: 1.1-25.9mIU/mL), were selected. As diurnal rhythm of both T-T and F-T was observed, blood samples were collected in the morning when T-T and F-T concentration were relatively stable at their high concentration levels. The collected samples were stored at-20 degree C until they were used for assays.<br>(Results) Reference range for T-T has decided to express by the mean+/-2SD calculated from the entire test results, because influence of aging on the results was negligible, Reference range of T-T has established as 2.01-7.50ng/mL. The other hand, reference ranges of F-T classified for every decade have decided to express by the mean+/-2SD of each decade subgroup, because great influence of aging on F-T was observed.<br>For each decade from 20 years on and >70 years, reference ranges of F-T have established as: 8.5-27.9pg/mL, 7.6-23.1pg/mL, 7.7-21.6pg/mL, 6.9-18.4pg/mL, 5.4-16.7pg/mL, and 4.5-13.8pg/mL, respectively.<br>(Conclusion) Reference ranges of serum T-T and F-T in Japanese male adults have established. And the value of Young Adult Mean (YAM) of F-T calculated for a group of the ages between 20 and 39 years have been proposed as a guideline of requirement for the Androgen Replacement Therapy (HRT). The value of 80% and 70% of YAM were 12.4pg/mL and 10.9pg/mL, respectively.

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