TREATMENT RESULTS OF SALVAGE RADIOTHERAPY FOR BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY

DOI Web Site PubMed 66 References Open Access

Bibliographic Information

Other Title
  • 前立腺全摘術後のＰＳＡ再発に対する救済放射線治療の検討
  • ゼンリツセン ゼンテキジュツゴ ノ PSA サイハツ ニ タイスル キュウサイ ホウシャセン チリョウ ノ ケントウ

Search this article

Description

(Purpose) In this retrospective study we reported the results of salvage external beam radiotherapy for patients with biochemical recurrence after radical prostatectomy.<br> (Materials and methods) A total of 28 patients with biochemical recurrence after radical prostatectomy underwent salvage radiotherapy with (n=16) or without (n=12) hormonal therapy. Median radiation dose was 60 Gy. Biochemical recurrence after radiotherapy was defined as a single prostate-specific antigen (PSA) of at least 0.1 ng/ml. Potential risk factors were evaluated for significant associations with biochemical recurrence.<br> (Results) The median follow-up period after salvage radiotherapy was 42 months. The actuarial biochemical recurrence free survival rate at 3 and 5 years was 81% and 74%, respectively. Addition of hormonal therapy to salvage radiotherapy did not alter biochemical recurrence rate (P=0.56). Univariate analysis revealed that Gleason score of 8 to 10 (P=0.026) and PSA before salvage therapy greater than 0.24 ng/ml (P=0.0016) were significant risk factors for biochemical recurrence. On multivariate analysis, PSA before salvage therapy greater than 0.24 ng/ml (P=0.017) maintained statistical significance. Of 28 patients 3 (11%) experienced late grade 3 toxicity of hematuria.<br> (Conclusion) Our data suggest that early use of salvage radiotherapy is beneficial for patients with biochemical recurrence after radical prostatectomy.<br>

Journal

References(66)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top