A CASE OF UROTHELIAL CARCINOMA OF THE URINARY BLADDER WITH SQUAMOUS DIFFERENTIATION RESPONDING TO PACLITAXEL AND CARBOPLATIN NEOADJUVANT CHEMOTHERAPY

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  • パクリタキセル・カルボプラチンによる術前補助化学療法が奏功した扁平上皮への分化を伴う膀胱尿路上皮癌の一例
  • 症例報告 パクリタキセル・カルボプラチンによる術前補助化学療法が奏功した扁平上皮への分化を伴う膀胱尿路上皮癌の一例
  • ショウレイ ホウコク パクリタキセル ・ カルボプラチン ニ ヨル ジュツゼン ホジョ カガク リョウホウ ガ ソウコウ シタ ヘンペイ ジョウヒ エ ノ ブンカ オ トモナウ ボウコウ ニョウロ ジョウヒガン ノ イチレイ

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Abstract

<p>A 42-year-old man was referred to our hospital for macrohematuria. Computer tomography and magnetic resonance imaging revealed right hydronephrosis and a retroperitoneal mass, located next to right side of the bladder. Cystoscopy showed a protruded lesion covered with normal mucosa at the right lateral wall. The patient underwent transurethral resection of the bladder tumor and biopsies of the bladder wall. Histological examination showed squamous cell carcinoma. Neoadjuvant chemotherapy using paclitaxel and carboplatin (TC) was performed. A total cystectomy, right nephroureterectomy and construction of the ileal conduit were performed after one course of systemic chemotherapy. Histological examination showed urothelial carcinoma with squamous cell differentiation. Unexpectedly, a small amount of CIS was detected only in the vicinity of the TUR scar. The patient received 2 cycles of TC chemotherapy as adjuvant chemotherapy. Unfortunately, 11 months later, local recurrence and liver metastasis were detected. He died 17 months after the surgery.</p>

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