CLINICAL OUTCOMES AFTER COMBINED THERAPY WITH DUTASTERIDE IN PATIENTS WITH UNSUCCESSFUL TRIAL WITHOUT CATHETER AFTER TREATMENT WITH AN ALPHA1-ADRENERGIC RECEPTOR BLOCKER MONOTHERAPY FOR ACUTE URINARY RETENTION CAUSED BY PROSTATIC HYPERPLASIA

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  • Inahara Masahiko
    Department of Urology, Teikyou University Chiba Medical Center
  • Sugiura Masahiro
    Department of Urology, Teikyou University Chiba Medical Center
  • Kaga Kanya
    Department of Urology, Teikyou University Chiba Medical Center
  • Hou Kyokusin
    Department of Urology, Teikyou University Chiba Medical Center
  • Araki Kazuhiro
    Department of Urology, Teikyou University Chiba Medical Center
  • Masuda Hiroshi
    Department of Urology, Teikyou University Chiba Medical Center
  • Kojima Satoko
    Department of Urology, Teikyou University Chiba Medical Center
  • Naya Yukio
    Department of Urology, Teikyou University Chiba Medical Center

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Other Title
  • 前立腺肥大によるα1アドレナリン受容体拮抗薬単独療法抵抗性の急性尿閉症例に対するデュタステリド併用療法の検討
  • ゼンリツセン ヒダイ ニ ヨル a1 アドレナリン ジュヨウタイ キッコウヤク タンドク リョウホウ テイコウセイ ノ キュウセイ ニョウヘイショウレイ ニ タイスル デュタステリド ヘイヨウ リョウホウ ノ ケントウ

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Abstract

(Objective) The outcome of trial of voiding without catheter in patients treated combination therapy with dutasteride and alpha1-adrenergic receptor blocker for acute urinary retention caused by benign prostatic hyperplasia was not reported. We evaluated the clinical efficacy of combination therapy with dutasteride in patients with unsuccessful trial without catheter after treatment with an alpha1-adrenergic receptor blocker monotherapy for acute urinary retention caused by benign prostatic hyperplasia. (Patients and methods) Patients with acute urinary retention due to prostatic hyperplasia were catheterized and treated alpha1-adrenergic receptor blocker monotherapy. After two weeks later, patients were put on trial without catheter. 52 patients who were unsuccessful trial without catheter administered combination therapy with dutasteride and alpha1-adrenergic receptor blocker. We use criteria that voiding urine volume over 100 ml and post-void residual urine volume below 100 ml in deciding whether catheter should be removed. (Results) 33 (63.5%) men did not require re-catheterization within 7 months after combination therapy. The successful rate of Performance Status (PS) 0-1 group was significantly superior to that of PS 2-4 group. (Conclusions) PS 0-1 men catheterized for AUR can void more successfully after catheter removal than PS 2-4 men if treated with combination therapy.

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