Posterior Disconnection in Early Infancy to Treat Intractable Epilepsy With Multilobar Cortical Dysplasia

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  • LIANG Qin-Chuan
    Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University
  • OTSUKI Taisuke
    Department of Neurosurgery, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry
  • TAKAHASHI Akio
    Department of Neurosurgery, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry
  • ENOKIZONO Takashi
    Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry
  • KAIDO Takanobu
    Department of Neurosurgery, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry
  • KANEKO Yuu
    Department of Neurosurgery, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry
  • NAKAGAWA Eiji
    Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry
  • SUGAI Kenji
    Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry
  • SASAKI Masayuki
    Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry

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タイトル別名
  • —Three Case Reports—

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説明

Extensive multilobar cortical dysplasias occasionally occur in children and can induce seizure onset in early infancy, causing severe epileptic encephalopathy. Surgical interventions in early infancy, such as disconnection of large parts of the brain, are challenging because of the degree of invasiveness and carry greater risks in infants compared with older children. Here we report the successful treatment of intractable epilepsy with multilobar cortical dysplasias in the posterior cortex by posterior disconnection in three infants (age 3 months). The patients showed good postoperative recovery and exhibited excellent seizure control at follow-up evaluation within a year after surgery. Developmental catch-up was also achieved and no early complications have been detected to date. Use of the posterior disconnection technique for early-stage extensive multilobar cortical dysplasias can result in good seizure control and developmental progress with little perioperative morbidity. However, the efficacy of this surgical technique needs to be verified with long-term follow up after surgery.<br>

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