BIOCHEMICAL AND FUNCTIONAL CHARACTERISTICS OF AUTONOMIC RECEPTORS IN NEONATAL URINARY TRACT SMOOTH MUSCLE

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  • 尿失禁に対する基礎的研究
  • 生下時家兎尿路平滑筋における自律神経受容体の分布と機能

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I investigated the biochemical (Bmax, KD) and functional (contractile force) characteristics of autonomic receptors in the 1-day-old rabbit urinary tract smooth muscle, and compared the data obtained to those already reported in adult rabbits. The rank order of the receptor densities in neonatal rabbits are dome>base>urethra>ureter for α1 (3H-PZ), ureter>urethra>base>dome for α2 (3H-YOH), dome>base>urethra>ureter for β(3H-DHA) and dome>base>urethra>ureter for muscarinic (3H-QNB). Unlike the findings in the adult rabbit, there is a much larger number of functional muscarinic receptors in the bladder dome and a much smaller number of functional α1-receptors in the urethra of neonatal rabbits. The differences observed in the pattern of distribution of these receptors between neonatal and adult urinary tracts may play a determinant role in the physiological development of the urinary system.

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