Serotonin-induced ion channel modulations in mesenteric artery myocytes from normotensive and DOCA-salt hypertensive rats

DOI Web Site 参考文献87件
  • Bae Young Min
    Artificial Muscle Research Center, Konkuk University Department of Physiology, College of Medicine, Konkuk University
  • Sung Dong Jun
    Artificial Muscle Research Center, Konkuk University Department of Physiology, College of Medicine, Konkuk University
  • Noh Hyun Ju
    Department of Physiology, College of Medicine, Konkuk University
  • Kim Junghwan
    Department of Physical Therapy, College of Natural Science, Yongin University
  • Park Sang Woong
    Artificial Muscle Research Center, Konkuk University Department of Physiology, College of Medicine, Konkuk University
  • Kim Bokyung
    Department of Physiology, College of Medicine, Konkuk University
  • Cho Sung Il
    Department of Physiology, College of Medicine, Konkuk University

書誌事項

公開日
2007
DOI
  • 10.1540/jsmr.43.85
公開者
日本平滑筋学会

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説明

Although serotonin (5-hydroxytryptamine, 5-HT) has been found to be a potent vasoconstrictor, a pivotal role of 5-HT in the control of appetite and mood control by the modulation of neuronal synapse has also been proposed. Selective 5-HT reuptake inhibitors (SSRIs) are frequently used to suppress appetite and treat depressive disorder, and the target protein of SSRIs is the 5-HT transporter (5-HTT) in the neuronal synapse. However, SSRIs may increase the free 5-HT concentration in circulating blood because platelets and vascular smooth muscles express functional 5-HTT. In addition, enhanced vasoactive action of 5-HT and alterations in 5-HT receptor subtypes have been reported in some types of hypertension. Therefore, we can infer that the use of drugs such as SSRIs in some hypertensive patients is potentially risky. Altered functional expression of ion channels in vascular smooth muscle is suggested to be a mechanism for the enhanced vasoconstriction by vasoactive agonists, including 5-HT. In this brief review, we compared the electrophysiological properties of mesenteric artery myocytes and their modulation by 5-HT between sham-operated control and deoxycorticosterone acetate (DOCA)-salt hypertensive rats.<br>

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