Visualization of viruses in living cells

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  • KAWAGUCHI Yasushi
    Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo

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Other Title
  • 生きた細胞におけるウイルスの可視化
  • イキタ サイボウ ニ オケル ウイルス ノ カシカ

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Abstract

Live-cell imaging of cells infected with recombinant viruses expressing fluorescently tagged structural viral proteins enables to visualize virion maturation pathways at a virion particle level in the same cells as infection progresses. This technology have gradually unveiled previously unreported aspects of the pathways. This article focuses on live-cell imaging technology of herpes simplex virus 1 (HSV-1) and reviews the up-to-date topics of HSV-1 maturation pathway including our recent progress.

Journal

  • Uirusu

    Uirusu 58 (2), 117-124, 2008

    The Japanese Society for Virology

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