Post-training <i>N</i>-methyl-D-aspartate receptor blockade facilitates retention of acquired spatial memory in rats
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- Shinohara Keisuke
- Doshisha University
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- Hata Toshimichi
- Doshisha University
Bibliographic Information
- Other Title
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- 獲得後のNMDA受容体阻害は空間記憶保持を向上させる
- カクトク ゴ ノ NMDA ジュヨウタイ ソガイ ワ クウカン キオク ホジ オ コウジョウ サセル
- Post-training N-methyl-D-aspartate receptor blockade facilitates retention of acquired spatial memory in rats
- N-methyl-d-aspartate receptor blockade facilitates retention of acquired spatial memory in Morris water maze
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Abstract
We investigated the effect of a post-training chronic infusion of N-methyl-d-aspartate (NMDA) receptor blocker on retention of spatial reference memory in rats. In Experiment 1, we trained 4 groups of rats for 4 days (4 trials/day) in the Morris water maze task. In a single probe trial after retention intervals of 1, 7, 14, and 28 days, the 1-day group showed more goal crossings than shown by the other 3 groups. In Experiment 2, a chronic infusion of the NMDA receptor antagonist d-2-amino-5-phosphonovaleric acid (d-AP5) or a control vehicle into the lateral ventricle was initiated 1 day after the training session, and continued for 6 days. In the subsequent probe trial (7 days after training), the rats that had received the d-AP5 infusion showed significantly more goal crossings than the controls. These findings suggest that an NMDA receptor blockade following acquisition facilitates retention of spatial reference memory.
Journal
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- The Japanese journal of psychology
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The Japanese journal of psychology 84 (6), 618-624, 2014
The Japanese Psychological Association
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Keywords
Details 詳細情報について
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- CRID
- 1390282680054431104
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- NII Article ID
- 130003395746
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- NII Book ID
- AN00123620
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- COI
- 1:STN:280:DC%2BC2crntlKrtA%3D%3D
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- ISSN
- 18841082
- 00215236
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- NDL BIB ID
- 025287109
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- PubMed
- 24669503
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed