Advances in research on HCV replication and virion formation

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  • SUZUKI Tetsuro
    Department of Virology II, National Institute of Infectious Diseases.
  • HARA Hiromichi
    Department of Virology II, National Institute of Infectious Diseases.
  • AIZAKI Hideki
    Department of Virology II, National Institute of Infectious Diseases.
  • SUZUKI Ryosuke
    Department of Virology II, National Institute of Infectious Diseases.
  • MASAKI Takahiro
    Department of Virology II, National Institute of Infectious Diseases.

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Other Title
  • Ｃ型肝炎ウイルスの複製と粒子形成
  • Cガタ カンエン ウイルス ノ フクセイ ト リュウシ ケイセイ

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Abstract

Hepatitis C virus (HCV) establishes a persistent infection and is recognized as a major cause of chronic liver diseases worldwide. Although much work remains to be done regarding the viral life cycle, significant progress has been made with respect to the molecular biology of HCV, especially the viral genome replication and virion formation. A variety of host cell factors, which play roles in replication of the viral genome RNA, have been identified. Involvement of lipid droplet, lipid metabolism and the viral nonstructural proteins in the production of the infectious particles has also been revealed.

Journal

  • Uirusu

    Uirusu 60 (1), 87-92, 2010

    The Japanese Society for Virology

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