The mechanisms of herpesvirus infection-virus entry into host cells and virus assembly.

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  • MORI Yasuko
    Laboratory of Virology and Vaccinology, National Institute of Biomedical Innovation

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  • ヘルペスウイルスの感染機構―特に宿主細胞への侵入および粒子成熟機構
  • ヘルペス ウイルス ノ カンセン キコウ トクニ シュクシュ サイボウ エノ シンニュウ オヨビ リュウシ セイジュク キコウ

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Abstract

Herpesvirus entry into host cells occurs by recognition of specific cellular receptor(s) with viral envelope glycoproteins. Nucleocapsids formed in nucleus are released into cytoplasm, and acquire tegument proteins there. Nucleocapsids with tegument proteins bud into intracellular vesicles formed in infected cells, which are thought to be derived from Golgi apparatus, trans-Golgi network or endosomes. However, the precise mechanisms involved in virus final envelopment are poorly understood. Here, I review our current knowledge regarding herpesvirus entry into host cells and virus assembly.

Journal

  • Uirusu

    Uirusu 57 (2), 151-158, 2007

    The Japanese Society for Virology

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