Cytomegalovirus (CMV)

KOSUGI Isao

doi:10.2222/jsv.60.209

Bibliographic Information

Other Title

ヘルペスウイルス（ＨＨＶ１‐８）のウイルス学　　３．サイトメガロウイルス（ＣＭＶ）

Description

Human cytomegalovirus (HCMV) is a ubiquitous beta human herpesvirus type 5. Compared to other human herpesviruses, HCMV is the largest, with a genome of ~235 kb containing ~250 ORFs with the potential to encode proteins. Usually, HCMV asymptomatically infects the host during childhood, and establishes life-long latency. The infection is life-threatening for infants and immunocompromised individuals, because of direct cytopathicity by viral replication, causing systemic organ injuries. Intrauterine infection occasionally causes microcephaly, sensorineural hearing loss and mental retardation. HCMV genome contains a number of accessory genes. Most of them are engaged in immune evasion or inhibition of cell death, possibly, resulting in a symbiosis between virus and host. CD34-positive myeloid progenitor cells are considered as a site of latency. However, the molecular mechanisms by which HCMV establishes and maintains latency and reactivates remain poorly understood. Recently in Japan, the decline of maternal HCMV seropositivity may increase the risk of intrauterine infection. It needs to immediately establish the protection against transplacental HCMV infection, such as a new type of neutralizing antibody or vaccine, which effectively interferes viral entry specific to endothelial and epithelial cells. Furthermore, HCMV infection might be considered as the most important factor for driving immune senescence in the elderly.

Journal

Uirusu

Uirusu 60 (2), 209-220, 2010

The Japanese Society for Virology

Details 詳細情報について

CRID: 1390282680054913536

NII Article ID: 130004470953

DOI: 10.2222/jsv.60.209

COI: 1:STN:280:DC%2BC3MvjtlKjtg%3D%3D

ISSN: 18843433; 00426857

PubMed: 21488334

Text Lang: ja

Article Type: journal article

Data Source

JaLC
Crossref
PubMed
CiNii Articles
OpenAIRE

Abstract License Flag: Disallowed

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