The role of Follicular helper CD4 T cells in HIV/SIV infection

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  • HIV/SIV感染におけるFollicular helper CD4 T細胞の役割
  • HIV/SIV カンセン ニ オケル Follicular helper CD4 Tサイボウ ノ ヤクワリ

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Abstract

Follicular CD4 T helper (TFH) cells promote the survival, isotype switching and generation of high affinity memory B cells and plasma cells. There are numerous reports regarding the dysfunction of B cell mediated immune responses, the lack of memory CD4 T cells and the dysfunction of HIV specific CD4 T cells in SIV/HIV infection. During chronic SIV/HIV infection, TFH cell accumulation may drive B cell dysfunction and become a major HIV reservoir. In this review, we discuss the relationship between TFH cells and B cells in SIV/HIV infection.

Journal

  • Uirusu

    Uirusu 62 (2), 161-166, 2012

    The Japanese Society for Virology

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