Mechanisms of EBV-mediated oncogenesis
Bibliographic Information
- Other Title
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- ウイルスと発癌 １．ＥＢウイルスによる発癌機構
- EBウイルスによる発癌機構
- EB ウイルス ニ ヨル ハツガン キコウ
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Abstract
Epstein-Barr virus (EBV) is the DNA tumor virus, which is known to be relevant to various cancers. EBV maintains latent infection in cancer cells, and there are three types of latent infection (type I-III) according to the patterns of viral latent genes expression. EBV has the ability to transform B cells into immortalized lymphoblastoid cell lines (LCL) showing type III latency, in which all latent genes are expressed. The mechanism of B-cell transformation has provided a model of EBV-associated lymphomas in immunosuppressed individuals. In type I and II latency, the limited numbers of latent genes are expressed. Previous studies have demonstrated the oncogenic functions of latent EBV genes including nuclear antigen EBNA1, membrane protein LMP1 and LMP2A. In addition, we have demonstrated that EBV-encoded small RNA EBERs play a significant role in oncogenesis. Here we summarize recent progresses in the studies on molecular mechanisms of EBV-mediated oncogenesis.
Journal
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- Uirusu
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Uirusu 56 (2), 201-208, 2006
The Japanese Society for Virology
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Keywords
Details 詳細情報について
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- CRID
- 1390282680054977152
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- NII Article ID
- 10018452069
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- NII Book ID
- AN00018808
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- COI
- 1:CAS:528:DC%2BD2sXjtVWgsbY%3D
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- ISSN
- 18843433
- 00426857
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- NDL BIB ID
- 8630579
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- PubMed
- 17446669
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed
