1973年岐阜県で流行した Hand, Foot and Mouth Disease におけるウイルス学的研究

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タイトル別名
  • EPIDEMIC OF HAND, FOOT AND MOUTH DISEASE IN GIFU PREFECTURE IN 1973
  • 1973ネン ギフケン デ リュウコウシタ Hand Footand Mout

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An epidemic of hand, foot and mouth disease (HFMD) occurred in Gifu Prefecture in 1973. Virological and serological investigation were performed.<br>Those involved ranged from 0 to 23 years of age, and 71.4% of them were under 4 years. Symptoms of the central nervous system (CNS) were observed concomitantly in 20 of 42 cases.<br>Viruses were isolated from 22 of 38 cases (57.9%). The types of isolated viruses with the number of cases of isolation are as follows: enterovirus 71 (16 cases; 42.1%), Coxsackievirus (Cox.) B5 (8 cases; 21.1%), Cox. A9 (2 cases; 5.2%), and unidentified virus (one case; 2.6%). Cox. A16 was not isolated at all. Eighteen strains of enterovirus 71 were isolated in Vero cells. One strain was isolated in suckling mice. The viruses isolated from cases of HFMD with CNS symptoms were identified as enterovirus 71 and Cox. B5.<br>In the cross-neutralization test, the isolated strains of enterovirus 71 showed a cross reaction to the prototype strain of enterovirus 71, but were antigenically broader than this strain. They showed no cross reaction to the prototype strain of Cox. A16.<br>A significant rise of neutralization antibody titer was found in 25% of 24 cases against enterovirus 71, 13% of 23 cases against Cox. B5, 4% of 24 cases against Cox. A 16, and 17% of 6 cases against Cox. A9.<br>It was supposed that the main causative agent of HFMD epidemic in Gifu Prefecture in 1973 might be enterovirus 71. The roles of the other viruses isolated, however, can not be neglected in the etiology of HFMD.

収録刊行物

  • ウイルス

    ウイルス 28 (2), 78-86, 1978

    日本ウイルス学会

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