Flaviviruses

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  • ISHIKAWA Tomohiro
    Department of Microbiology, Dokkyo Medical University School of Medicine
  • KONISHI Eiji
    BIKEN Endowed Department of Dengue Vaccine Development, Faculty of Tropical Medicine, Mahidol University

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  • フラビウイルス

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Description

Family Flaviviridae genus flavivirus contains numerous pathogenic viruses such as Japanese encephalitis virus, dengue virus, West Nile virus, etc, which cause public health problems in the world. Since many mammals and birds can act as amplifying hosts and reservoir hosts in nature and those viruses are transmitted by haematophagous mosquitoes or ticks, those viruses could not be eradicated from the nature. In the recent few decades, the viral replication mechanism and the ultrastructure of viral proteins as well as the viral immune evasion mechanism have been elucidated extensively, leading to develop novel types of antivirals and vaccines. In this review, the flavivirus nature and epidemiology, replication mechanism, immune response and immune evasion, and antivirals and vaccines against flaviviruses were described.

Journal

  • Uirusu

    Uirusu 61 (2), 221-238, 2011

    The Japanese Society for Virology

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